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A few of these bioreactor designs have been commercialized. Examples of commercial technologies include the Escherichia coli large-scale fermentors for commercial production of lysate and recombinant proteins, the ammonium-utilizing bioreactor for lactic acid production, and the poly-3-hydroxybutyrate (PHB) bioreactor for commercial production of PHB copolymer plastics. A review of such bioreactor systems is provided by Kramer et al., Biotechnol. Bioeng., 34:160 (1991).
All of the existing bioreactors are limited in their design, operation, and product yield capacity. Some of the problem areas include the requirement for complex and tedious purification of products from these systems, variable performance during operation and, in the case of PHB bioreactors, limited yields and high volumetric input requirements for the raw materials.
One of the existing commercial bioreactors is the Ammonium-utilizing Bioreactor (AUB). This device is designed to produce large amounts of lactic acid from a mixture of glucose and ammonium compounds. It consists of two tubular reactors, one containing the organic substrate and the other containing the ammonium sulfate, which is present in very high concentration. The high concentration of ammonium sulfate prevents the mineralization of the organic substrate to ammonium carbonate. The latter acts as a buffer to regulate the pH within the reactor, thus increasing the yield of lactic acid from the organic substrate. The external ammonium is https://ksvgraphicstt.com/wp-content/uploads/2022/06/Cutting_Planner_Pro.pdf
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Assassin’s Creed: Syndicate – Gold Edition [v1.51 + All DLCs + MULTi16]. Minimum size of Repack is 19.1 GB – Read NFO below. DLCs
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